In this article, we provide an overview of the similarities and differences between naproxen and ibuprofen, including:. Naproxen and ibuprofen reduce inflammation by preventing an enzyme from making prostaglandins. Prostaglandins are a critical factor for inflammation.
Doctors link chronic inflammation with various health conditions, including inflammatory bowel disease IBD and some forms of arthritis. Heat, redness, pain, and swelling are signs of inflammation. People may experience pain relief that can occur shortly after taking an NSAID , but it can take weeks for the inflammation to go away.
When prostaglandins reach the brain, they can cause fever that naproxen and ibuprofen can also treat. By blocking the enzyme that produces prostaglandins, NSAIDs can impair platelet activity, hindering blood clots from forming.
However, some people should not take ibuprofen, such as those who are taking aspirin for heart protection.
People may use NSAIDs for a short period early in rheumatoid arthritis, while other medications take effect. Naproxen is available in two forms: Naproxen and naproxen sodium. The body absorbs naproxen sodium better than naproxen.
Doses are in milligrams mg in the table below:. Although available over the counter, naproxen and ibuprofen may not be safe for people with the following conditions:. People who take prescription naproxen or ibuprofen may have increased risks for:. The risk of cardiovascular events, clots, heart attack, and stroke may be higher in people with a history of cardiovascular disease or risk factors for cardiovascular disease.
If taking NSAIDs within 2 weeks after heart surgery, people may be at an increased risk for heart attack and stroke. People who take naproxen or ibuprofen may have a greater risk of developing high blood pressure , heart failure , and water retention.
Older adults are more vulnerable to these severe side effects. People who take over-the-counter naproxen and ibuprofen at the labeled dose for 7—10 days may not have an increased risk of adverse effects. To minimize the risk for these adverse effects, people should take naproxen or ibuprofen at the lowest dose for the shortest length of time. Is taking aspirin good for your heart? Aspirin for prevention of cardiovascular disease. Slomski A. Daily aspirin increases gastrointestinal bleeding among older adults.
Answers about aspirin. Updated January 1, University of Michigan Health Lab. Two ways to reduce blood thinner risks that lead to GI bleeding. Updated March 22, American Heart Association. Aspirin and heart disease. Updated March 20, University of Michigan, Michigan Medicine. Reye syndrome. Updated May 27, Updated March 15, Updated April Clinical pharmacology and cardiovascular safety of naproxen. Am J Cardiovasc Drugs. Drini M.
Peptic ulcer disease and non-steroidal anti-inflammatory drugs. Aust Prescr. National Kidney Foundation. Pain medicines analgesics. Updated February 25, Can you double up on pain killers?
Updated March 9, American Academy of Family Physicians. OTC medicines and pregnancy. Risk comparison for prenatal use of analgesics and selected birth defects, National Birth Defects Prevention Study Ann Epidemiol. Updated December 16, A comparison of the effect of non-steroidal anti-inflammatory drugs versus acetaminophen in symptom relief for the common cold: A meta-analysis of randomized controlled trial studies.
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Table of Contents View All. Table of Contents. Frequently Asked Questions. What Is Chronic Inflammatory Disease? Headache Treatment: Tylenol or Advil? Acetaminophen Warnings Acetaminophen liver toxicity is a serious problem in the U. Aspirin Warnings Aspirin should be avoided in children with fever due to the risk of Reye's syndrome , which is a form of encephalopathy a brain disease. Ibuprofen Warnings Ibuprofen and all NSAIDs except aspirin may increase your risk of heart attack or stroke, which can happen suddenly and be fatal.
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What's the Difference Between Advil and Aleve? How Is Radiation Sickness Treated? Arthritis Treatment Goals and Options. Taking more than the recommended dosage of ibuprofen or drinking a lot of alcohol significantly raises your risk of serious problems.
Find out how. Ibuprofen and acetaminophen are drugs for mild to moderate pain. Learn how they compare. To avoid the side effects and possible toxicity of medications, you might turn to natural painkillers instead.
Check out these five surprising options. Need to get rid of a fever fast? Read about side effects, warnings, and other factors to help you decide which fever reducer is best for you or your…. A new study looking into adverse effects from medication use found that anticoagulants and diabetes agents send a significant amount of adults ages 65…. Health Conditions Discover Plan Connect. Ibuprofen vs.
What ibuprofen and naproxen do. Side effects. Use with other conditions. Read this next.
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