Before using this medicine, consult your doctor or pharmacist if you have:. Before using this medication, tell your doctor or pharmacist your medical history, especially of:. This drug may make you drowsy. Alcohol or marijuana cannabis can make you more drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely.
Limit alcoholic beverages. Talk to your doctor if you are using marijuana cannabis. In general, alcohol is not recommended for pregnant or possibly pregnant women due to increased risk of harm to the baby.
Although unlikely, blood clots may occur with this medication. Your risk is increased if you have surgery or if you stay in a chair or bed for a long time such as on a long plane flight. Tell your doctor beforehand of any of these events because you may need special precautions. This medication may be used during pregnancy, but only as directed by your doctor.
Discuss the risks and benefits with your doctor. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Do not use other vaginal products during treatment with this medication unless otherwise directed by your doctor. Doing so may affect how well the drug is absorbed by your body.
This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call Otherwise, call a poison control center right away. US residents can call their local poison control center at Canada residents can call a provincial poison control center. If you miss a dose, use it as soon as you remember. However, do not use more doses in a day than prescribed. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time.
Do not double the dose to catch up. Store at room temperature at 77 degrees F 25 degrees C. Brief storage between degrees F degrees C is permitted. Keep all medicines away from children and pets. Natural progesterone, which is used during fertility treatment, poses no threat to a mother and child. It is important to note that the Food and Drug Administration FDA does not differentiate between natural progesterone and synthetic progesterone progestins in its warnings.
Progestins are mostly used to suppress ovulation and are found in birth control pills. They are only used in preparation for fertility treatment. In older studies synthetic progestins have been linked to a slightly increased risk of certain birth defects if used during pregnancy.
The FDA has conducted a thorough review of relevant published studies and has found there is no increase in birth defects resulting from exposure to any progesterone in early pregnancy. During fertility treatment, a woman may be prescribed the following progesterone supplements in these common doses:.
These three routes noted above have been shown to be equally effective in fertility treatment. Less reliable are:. In the past, intramuscular injections were commonly used as a result of the lack of other available preparations. Multiple studies have shown no difference in the outcome of IVF treatment when compared to vaginal progesterone, and some even have even shown superiority of vaginal progesterone.. An additional advantage of vaginal progesterone is that it does not cause the pain of intramuscular progesterone injections.
In some circumstances, combinations of different types of progesterone may be prescribed. Compared to other fertility drugs, progesterone tends to be less expensive, and insurance generally covers one form or another.
Patients who have had an allergic reaction to one form of progesterone should be switched to another form, even in the middle of treatment. Side effects specific to a certain form of progesterone are also a reason to switch. What role does progesterone play in fertility, conception and pregnancy?
What infertility issues does progesterone help to address? However, it will not hurt you or your partner to have intercourse with the suppository in place and should not interrupt your sex life. You may find that it is more comfortable to wear a minipad during the day when using PVS as they will melt and create a light discharge. Are there any side effects or complications from PVS?
PVS are one of the safest treatments available as they contain only natural progesterone. An occasional woman will complain of irritation or unpleasant discharge with PVS, but the great majority of women have no problems at all.
There are no known serious side effects from PVS and there is no known risk to the baby during pregnancy. PVS have been widely used for many years and are considered very safe. Are there any special instructions? PVS should be kept in the refrigerator as they will melt if they get very warm.
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